White matter development in the early stages of psychosis

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White matter tractography in early psychosis: clinical and neurocognitive associations.

BACKGROUND While many diffusion tensor imaging (DTI) investigations have noted disruptions to white matter integrity in individuals with chronic psychotic disorders, fewer studies have been conducted in young people at the early stages of disease onset. Using whole tract reconstruction techniques, the aim of this study was to identify the white matter pathology associated with the common clinic...

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White-matter hyperintensities in first-episode psychosis

BACKGROUND White-matter hyperintensities have been associated with both schizophrenia and mood disorders, particularly bipolar disorder, but results are inconsistent across studies. AIMS To examine whether white-matter hyperintensities are a vulnerability marker for psychosis or are specifically associated with bipolar disorder. METHOD T(2)-weighted magnetic resonance imaging data were acqu...

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Alterations in White Matter Evident Before the Onset of Psychosis

BACKGROUND Psychotic disorders are associated with widespread reductions in white matter (WM) integrity. However, the stage at which these abnormalities first appear and whether they are correlates of psychotic illness, as opposed to an increased vulnerability to psychosis, is unclear. We addressed these issues by using diffusion tensor imaging (DTI) to study subjects at ultra high risk (UHR) o...

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White matter development and early cognition in babies and toddlers

The normal myelination of neuronal axons is essential to neurodevelopment, allowing fast inter-neuronal communication. The most dynamic period of myelination occurs in the first few years of life, in concert with a dramatic increase in cognitive abilities. How these processes relate, however, is still unclear. Here we aimed to use a data-driven technique to parcellate developing white matter in...

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ژورنال

عنوان ژورنال: Schizophrenia Research

سال: 2015

ISSN: 0920-9964

DOI: 10.1016/j.schres.2014.05.021